Human Trials Envisioned After Scientists Reverse Aging In Mammals

longevityPhoto: Octogenarian Olympian Johanna Quass (86) of Saxony, Germany (April 2012). Courtesy of Common Constitutionalist
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Gene modification in humans is a huge field that is set to explode within a few years, giving hope to Transhumans that immortality is just one step away. Technocrat scientists are racing for the gate to be first to hit the next big breakthrough.  TN Editor

An end to grey hair and crows-feet could be just 10 years away after scientists showed it is possible to reverse ageing in animals.

Using a new technique which takes adult cells back to their embryonic form, US researchers at the Salk Institute in California, showed it was possible to reverse ageing in mice, allowing the animals to not only look younger, but live for 30 per cent longer.

The technique involves stimulating four genes which are particularly active during development in the womb. It was also found to work to turn the clock back on human skin cells in the lab, making them look and behave younger.

Scientists hope to eventually create a drug which can mimic the effect of the found genes which could be taken to slow down, and even reverse the ageing process. They say it will take around 10 years to get to human trials.

Our study shows that ageing may not have to proceed in one single direction,” said Dr Juan Carlos Izpisua Belmonte, a professor in Salk’s Gene Expression Laboratory. “With careful modulation, aging might be reversed.

“Obviously, mice are not humans and we know it will be much more complex to rejuvenate a person. But this study shows that ageing is a very dynamic and plastic process, and therefore will be more amenable to therapeutic interventions than what we previously thought.”

Scientists have known for some time that the four genes, which are known collectively as the Yamanaka factors, could turn adult cells back to their stem cell state, where they can grow into any part of the body.

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