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First, there were plain vanilla mRNA "vaccines." Now, geneticists have created "self-amplifying mRNAs, or replicons, that provide long-lasting humoral and cellular immune responses upon single, low-dose immunization." This is a second-generation development that promises to take center stage in future pandemic preparedness. The paper, Rise of the RNA machines – self-amplification in mRNA vaccine design, is very clear. Japanese scientists are calling for a full stop.