Synthetic Human Embryos: No Need For Eggs Or Sperm

A roller culture incubator used to grow synthetic mouse embryos in an earlier experiment in 2022. Photograph: Ahmad Gharabli/AFP/Getty Images
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At the same time when synthetic wombs are being created, genetic scientists are perfecting synthetic embryos, where traditional eggs and sperm are not required. This scenario is reminiscent of Aldous Huxley’s book, Brave New World, where all babies were created in a test tube and incubated to term in an artificial womb. ⁃ TN Editor

Scientists have created synthetic human embryos using stem cells, in a groundbreaking advance that sidesteps the need for eggs or sperm.

Scientists say these model embryos, which resemble those in the earliest stages of human development, could provide a crucial window on the impact of genetic disorders and the biological causes of recurrent miscarriage.

However, the work also raises serious ethical and legal issues as the lab-grown entities fall outside current legislation in the UK and most other countries.

The structures do not have a beating heart or the beginnings of a brain, but include cells that would typically go on to form the placenta, yolk sac and the embryo itself.

Prof Magdalena Żernicka-Goetz, of the University of Cambridge and the California Institute of Technology, described the work in a plenary address on Wednesday at the International Society for Stem Cell Research’s annual meeting in Boston.

“We can create human embryo-like models by the reprogramming of [embryonic stem] cells,” she told the meeting.

There is no near-term prospect of the synthetic embryos being used clinically. It would be illegal to implant them into a patient’s womb, and it is not yet clear whether these structures have the potential to continue maturing beyond the earliest stages of development.

The motivation for the work is for scientists to understand the “black box” period of development that is so called because scientists are only allowed to cultivate embryos in the lab up to a legal limit of 14 days. They then pick up the course of development much further along by looking at pregnancy scans and embryos donated for research.

Robin Lovell-Badge, the head of stem cell biology and developmental genetics at the Francis Crick Institute in London, said: “The idea is that if you really model normal human embryonic development using stem cells, you can gain an awful lot of information about how we begin development, what can go wrong, without having to use early embryos for research.”

Previously, Żernicka-Goetz’s team and a rival group at the Weizmann Institute in Israel showed that stem cells from mice could be encouraged to self-assemble into early embryo-like structures with an intestinal tract, the beginnings of a brain and a beating heart. Since then, a race has been under way to translate this work into human models, and several teams have been able to replicate the very earliest stages of development.

The full details of the latest work, from the Cambridge-Caltech lab, are yet to be published in a journal paper. But, speaking at the conference, Żernicka-Goetz described cultivating the embryos to a stage just beyond the equivalent of 14 days of development for a natural embryo.

The model structures, each grown from a single embryonic stem cell, reached the beginning of a developmental milestone known as gastrulation, when the embryo transforms from being a continuous sheet of cells to forming distinct cell lines and setting up the basic axes of the body. At this stage, the embryo does not yet have a beating heart, gut or beginnings of a brain, but the model showed the presence of primordial cells that are the precursor cells of egg and sperm.

“Our human model is the first three-lineage human embryo model that specifies amnion and germ cells, precursor cells of egg and sperm,” Żernicka-Goetz told the Guardian before the talk. “It’s beautiful and created entirely from embryonic stem cells.”

The development highlights how rapidly the science in this field has outpaced the law, and scientists in the UK and elsewhere are already moving to draw up voluntary guidelines to govern work on synthetic embryos. “If the whole intention is that these models are very much like normal embryos, then in a way they should be treated the same,” Lovell-Badge said. “Currently in legislation they’re not. People are worried about this.”

There is also a significant unanswered question on whether these structures, in theory, have the potential to grow into a living creature. The synthetic embryos grown from mouse cells were reported to appear almost identical to natural embryos. But when they were implanted into the wombs of female mice, they did not develop into live animals. In April, researchers in China created synthetic embryos from monkey cells and implanted them into the wombs of adult monkeys, a few of which showed the initial signs of pregnancy but none of which continued to develop beyond a few days. Scientists say it is not clear whether the barrier to more advanced development is merely technical or has a more fundamental biological cause.

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About the Editor

Patrick Wood
Patrick Wood is a leading and critical expert on Sustainable Development, Green Economy, Agenda 21, 2030 Agenda and historic Technocracy. He is the author of Technocracy Rising: The Trojan Horse of Global Transformation (2015) and co-author of Trilaterals Over Washington, Volumes I and II (1978-1980) with the late Antony C. Sutton.
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“Scientists say these model embryos…could provide a crucial window on the impact of genetic disorders and the biological causes of recurrent miscarriage.”

What a load of crap. It’s always the same lie, over and over and over. Apparently, it works on the stoopids again and again and again.

The work is touted as beneficial to REAL, living humans but is clearly not. It’s about human cloning.

Last edited 3 months ago by Elle

Human replacement too.


Robots with human skin. They will create humans that look and behave as the TPTB want with no free will of their own and no soul. Yuval Hurari said this is the plan. Why do you think the current generation is called Gen Z? They are the last generation of actual organically created humans.


Ich habe heute mal die Themen von Guterres’ Our Common Agenda studiert. Der alte Kommunist kennt in seiner Schönen Neuen Welt nur Frauen und Jugend. Ich schließe, dass er Männer und Menschen Ü40 generell für verzichtbar hält. Bleibt die Frage, was er dann noch hier macht. Ein Pädo-Harem für die Superreichen? Wir leben in Zeiten, in denen das kein zynischer Witz ist.

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It’s possible that I could rejoice in modern-day technology, if evil motives and/or evil intentions wasn’t behind most of it.


WHY? Seriously…WHY?? The natural organic world works just fine for millions of years. Why do these people want to destroy it and replace it with something artificial? They’re already rich so it can’t be a monetary issue. The only thing that makes sense is that some demonic force is behind this. Only something not human would want to do this.

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